Besides, these carriers-assisted nanoparticles are risky of disassembly in lipophilic environment. Although adding external carriers could help conventional J-aggregates stabilize, such methods still suffer from high-concentration dependence and are unsuitable for activatable probes design. However, due to weak intermolecular interactions, conventional J-aggregates are easily decomposed into monomers in the biological environment. J-aggregation, an effective strategy to extend wavelength, has been considered as a promising method for constructing NIR-II fluorophores.
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